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15,16 Therefore, a balance exists in how folate is distributed between these two metabolic pathways, with competition for the 5,10-methyleneTHF cofactor existing at the nexus of these pathways

It is also important to note that the increase in efficacy of the drug regimen did not correlate with any increase in toxicity to healthy tissues (Murphy 2011)

The inhibition of both NAMPT activities can repolarize myeloid cells and inhibit tumor growth, especially in combination with immune checkpoint therapies

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