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Or is it to do with the sheer amount of work B12 has to do in the body
The key protease responsible for the processing of the proglucagon peptide into GLP-1 is Psck1/3, which has shown to be upregulated in -cells during hyperglycaemic, hyperlipidemic, or inflammatory conditions to promote glucose-induced glucagon suppression, a compensatory response to a metabolic insult as in type 2 diabetes (205)
Rossing P, Baeres FMM, Bakris G et al (2023) The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease
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