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A landmark 2025 meta-analysis published in the Journal of the American College of Cardiology pooled 21 randomized controlled trials covering 99,599 patients and found high-certainty evidence that GLP-1 receptor agonists produced: 12% reduction in all-cause death (IRR 0.88
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This hormone stimulates insulin release from the pancreas, suppresses glucagon secretion, slows gastric emptying, and acts on the brain to reduce appetite
Unlike retinoids, which have well-documented teratogenic effects and are contraindicated in pregnancy, copper peptides have no known mechanism for fetal harm
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