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These findings align with preclinical data showing that circadian disruption enhances TNBC tumor growth and impairs the time-dependent efficacy of cisplatin therapy, suggesting that both intact circadian signaling and melatonin rhythms are crucial for optimizing chemotherapeutic outcomes 58
Functional assessment Reduced efficacy represents the most reliable degradation indicator but requires prior experience with functional product
(See our AI policy here .) SAN DIEGO Weight loss, type 2 diabetes, sleep apnea, liver disease, heart disease cancer
Hypothalamic-pituitary-adrenal (HPA) axis and cortisol dysregulation The dysregulation of the HPA axis is a significant pathway linking depression with T2DM [70]
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