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Its half-life is short (7 minutes) because it is rapidly cleaved by dipeptidyl peptidase-IV (DPP-IV) after residues 2-3

This similarity often leads to dangerous delays in diagnosis, as patients experiencing stomach pain and healthcare providers may initially attribute symptoms to expected medication side effects rather than recognizing them as signs of pancreatic inflammation

Considerations for Patients with Malabsorption Disorders Those with malabsorption issues, like celiac disease or Crohns disease, might need more B12

Why Rybelsus May Lead to Digestive Side Effects Understanding why Rybelsus causes digestive side effects requires knowledge of its pharmacological mechanism