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NO is involved in normal cell signaling, contributing to the regulation of various physiological functions [141, 142] including activation of soluble guanylyl cyclase (sGC) which generates cyclic GMP (cGMP) [143]

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Cellular Senescence and Aging Research Senescent cells accumulate naturally with age and contribute to: Chronic inflammation Tissue dysfunction Reduced regenerative capacity Biological aging Research involving FOXO4-DRI investigates its potential role in selectively clearing these dysfunctional cells to support healthier tissue environments