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In the withdrawal trial, continuing preserved loss far better than switching to placebo, which regained about 14% over a year. The metabolic benefit fades in proportion to the weight regained, so a taper plus protein and resistance training beats a hard stop
W., Poppitt, S
Semaglutide's STEP 1 trial (1,961 subjects, 68 weeks) demonstrated 14.9% mean weight loss
A safe, compliant pathway is to use licensed telehealth or in-person clinics that can evaluate your symptoms, confirm deficiency when appropriate, and prescribe an approved product
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