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For patients who want to reduce their dose after reaching goal weight, a gradual tapering approach works best

First, although we initially planned to include five mice per group, one animal in the tirzepatide-treated group died just before drug administration (day 0), and an additional mouse died on day 10 after treatment initiation

Randomized controlled trials, observational studies, meta-analyses, and pharmacovigilance reports evaluating GI adverse effects of GLP-1based therapies were included

Patients who spread food intake across five smaller meals instead of three large ones report fewer nausea episodes during the adjustment phase