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359 , eaan2788 (2018)

In this study, we have implemented experimentally verified computational simulations of respiratory transport and drug delivery to illustrate that simple tweaks to the nasal spray direction can result in vastly improved drug deposition at the critical viral infection sites inside the nose

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BH3 peptides/mimetics in DTEP buffer (300 mM trehalose, 10 mM HEPES-KOH, 0.1% w/v BSA, 1 mM EDTA, 1 mM EGTA, 80 mM KCl, 5 mM succinate, final pH 7.4) were plated at 70 M l 1 (unless otherwise stated) in triplicate in a black 384-well plate