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Cyanocobalamin is the most widely available synthetic form, is shelf-stable, and is FDA-approved for treating B12 deficiency

Indications: In disorders requiring parenteral administration of vitamins, that is, pre- and postoperative treatment, when requirements increase as in fever, severe burns, increased metabolism, pregnancy, gastrointestinal disorders that interfere with the intake or absorption of vitamins, diseases prolonged or debilitating, alcoholism and where other deficiencies exist

The FDA cautions that both Wegovy and Zepbound may not be suitable for use during pregnancy, as these medications may harm the fetus

Targets nicotinamide N-methyltransferase (NNMT)