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Biofilm-forming organisms may contribute to: Ongoing inflammatory signaling Reduced melanocyte-stimulating hormone (MSH) Impaired immune resolution (17) Because biofilms protect organisms from immune clearance, unresolved colonization may perpetuate inflammatory patterns even after environmental exposure has been addressed

The foundational mechanism paper that established MOTS-c as a therapeutically relevant peptide is also worth citing directly: a peer-reviewed Cell Metabolism study by Lee and colleagues showing that the mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance through the AMPK pathway

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