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Furthermore, our study provides a validated framework for ranking DM2 DMTs based on their predicted impact within the DM2-AD comorbidity network, offering a data-driven approach to identify therapies with the highest potential for AD prevention

The first six amino acids at the N-terminus of GLP-1 are gone, and the alanine at position 8 is changed to the unnatural dimethyl version (Aib, 2-aminoisobutyric acid) thats to prevent enzymatic breakdown by the DPP-IV enzyme in vivo