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Direct clinical trials specifically testing GLP-1 agents with oral contraceptives are limited, which is why providers take a cautious approach

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By mimicking the action of the GLP-1 hormone, semaglutide helps to reduce appetite and increase feelings of fullness and satiety after meals

Increases in resting heart rate are a recognised class effect of incretin-based therapies and have been reported with GLP-1 receptor agonists more broadly, as reflected in the Summary of Product Characteristics (SmPC) for licensed agents such as semaglutide (Wegovy) and liraglutide (Saxenda)