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The study protocol and procedures were in accordance with the ethical standards outlined in the Declaration of Helsinki and its later amendments (21) and approved by the ethical committee of IUMS (ethical code: IR.MUI.REC.1395.3.929)

Pathogens or cellular debris induce heightened expression of pro-inflammatory cytokines such as IFNs and LPS, prompting microglial activation from a resting state (47)