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doi: 10.3389/fmicb.2022.979719 Received 27 June 2022 Accepted 14 September 2022 Published 06 October 2022 Volume 13 - 2022 Edited by Wanbo Tai, Shenzhen Bay Laboratory, China Reviewed by Lihui Guo, University of Amsterdam, Netherlands

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Originally developed to study metabolic disorders and insulin resistance , 5-Amino-1MQ has now gained attention in fitness and longevity circles for its ability to: Reduce fat cell size Increase NAD levels (critical for energy and mitochondrial function) Enhance insulin sensitivity and metabolic efficiency When NNMT is overactive as is often the case with obesity, aging, and chronic disease it limits the availability of nicotinamide and reduces NAD production

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