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If you experience any unusual symptoms or allergic reactions whilst taking medicine, please discontinue the use and consult your doctor immediately

The blue dashed curve is a power-law function fitted to the same data points

This review integrates mechanistic insights with translational advances, outlining how dysregulation of chaperones, autophagy-mitophagy, the ubiquitinproteasome system, and ER stress pathways drive human diseases, while highlighting emerging therapeutic platforms, from pharmacological chaperones and autophagy modulators to targeted protein degradation technologies, CRISPR screens, spatial biology, and AI-guided drug discovery

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