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Whether microdoses produce clinically meaningful appetite regulation remains uncertain
These effects are therapeutically useful for diabetes and obesity management, but they may complicate fasting assumptions before anesthesia or deep sedation
A third incretin-based approach is tirzepatide, a dual agonist of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR), which achieves greater HbA1c reduction and weight loss compared with GLP-1RAs alone
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