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2017 Apr 4;7:127-140
These rules include pharmacopoeia standards, stability studies, and impurity analysis
A 2021 study published in the New England Journal of Medicine showed that people on semaglutide lost 14.9% of their body weight over 68 weeks versus 2.4% in the placebo group
Although these changes in HR upon GLP-1 RA administration were subtle and the underlying mechanisms are unclear, further studies are necessary to elucidate the long-term effects of GLP-1 RAs primarily on HR and other related variables to clarify whether the elevated HR can be regarded as a transient reflex mechanism or whether it might in fact lead to poor cardiovascular outcomes in a diabetic population
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