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As a result, taking these medications together may lead to higher levels of methotrexate in the blood
Toxicology assessments in rats found no organ toxicity at doses up to 10 mg/kg (approximately 1000x the effective dose), no mutagenicity in Ames testing, and no teratogenic effects
In addition to being used as a staining agent in medical imaging and surgery, methylene blue is FDA-approved as a first-line antidote for methemoglobinemia and used off-label in cases of cyanide poisoning, carbon monoxide toxicity, and certain drug-induced conditions
(5) meet the requirements of Helsinki declaration
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