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Semaglutide has been shown in clinical trials to be an effective treatment for weight loss when combined with lifestyle modifications such as diet and exercise

Furthermore, exenatide suppressed plasma concentrations of GF (Transforming growth factor), the cytokine contributed to the pathogenesis of diabetic nephropathy (Figure 5)

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Therefore, the glycaemic improvement in animals treated with a GLP-1R/GcgR co-agonist is attributable to body-weight-independent and -dependent effects