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Annu Rev Med 74:125139
GLP-1R triggers various intracellular signaling pathways, such as the cAMP/PKA and PI3K/Akt pathways, by binding to endogenous GLP-1 or exogenous agonists, resulting in the enhancement of insulin secretion, inhibition of glucagon secretion, as well as anti-inflammatory and antioxidant stress response
Elevated TMAO levels were connected to severe illness states and a poor prognosis, with higher levels indicating worse outcomes even when controlling for confounders
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