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While these specific proteins were not significantly elevated in the sibling validation cohort, computational predictions based on (s)PLS-DA analysis did identify proteins associated with immunity and inflammatory responses such as Zinc-alpha-2-glycoprotein (AZGP1) and Carboxypeptidase B2 (CPB2) as being important contributors to group separation 48,49,50

Proinflammatory cytokines play a key role in astrocytic transformation, promoting increased APP expression, -site APP cleaving enzyme 1 activity and secreted A levels, all of which are linked to neurodegenerative disease pathology 90

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Parisy V, Poinssot B, Owsianowski L, Buchala A, Glazebrook J, Mauch F (enero de 2007)