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Research suggests GHK-Cu may upregulate genes associated with tissue repair and antioxidant defense while downregulating genes associated with inflammation and tissue degradation

Also, hormonal changes that occur at certain stages of life, such as menopause in women, can cause collagen breakdown, dryness, sagging skin and wrinkles, but also greater bone porosity and joint sensitivity

Treatment of HepG2 cells with different concentrations of NFT or DEM for 24 h led to a concentration-dependent increase in Nrf2 and GCLC protein levels, whereas no significant change was observed in the levels of the modifier subunit, GCLM (Fig