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These discrepancies are presumed to reflect differences in cultural background, educational systems, underlying liver disease characteristics, diagnostic methods, the definitions of CHE and MHE, and the approaches used to determine cutoff values

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17,18 In a post-hoc analysis of the SUSTAIN-6 study, the additional risk factors of speed of hemoglobin A1c reduction with treatment, poor baseline glycemic control and insulin use at the initiation of GLP-1/GIP agonist treatment were reported ( Table 2 )

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