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ROS damages the genetic code of the enzymes involved in transmethylation and transsulfuration and increases the degradation of GSH and the free radical hydrogen sulfide (H2S) produced
TMAO has also been shown to induce inflammatory markers in mice and in human aortic endothelial cells and vascular smooth muscle cells owing to activation of MAPK, extracellular signal kinase, and NF-B signaling cascade, along with promoting the recruitment of activated leukocytes to endothelial cells
381 Several clinical trials have demonstrated that FMT can reshape the gut microbiota, activate immune cells within the TME, and increase objective response rates by approximately 3060%, with manageable adverse effects
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