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Proteins such as tau, TDP-43, -synuclein, and polyglutamine-expanded proteins misfold and aggregate into toxic species that overwhelm the UPS and interfere with normal degradation processes
Additional evidence underscores the importance of leucine availability for optimizing the anabolic response to both feeding and exercise in older adults (66)
Despite extensive investigation, the precise molecular determinants governing the transition from adaptive UPR signaling to apoptosis remain incompletely understood
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