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When these molecules outweigh the body's antioxidant defenses, a state called oxidative stress occurs

PLoS ONE (2014)

Elevated levels of IL1A , IL1B , and IL1RN were observed in MAC.2 and Inf.MAC cells in TCMR, while significant IL1RL1 elevation was noted exclusively in migDCs in ABMR, suggesting a mixed inflammatory pattern of IL-1 cytokines in rejection samples ( Figure 5F )