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Patients with favorable genetic profiles may reach goal weight on lower doses (preserving medication cost and minimizing side effects), while those with less-responsive variants can switch to dual-compound protocols like GLP-Squared Injection ($289 monthly) earlier in treatment
This process helps the medical team decide the right dosage and treatment pace for safe fat loss
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The STEP 4 trial showed that patients who stopped semaglutide after 68 weeks of treatment regained, on average, two-thirds of their lost weight within 52 weeks of discontinuation (Rubino et al., NEJM, 2021)
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