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Many of these metal-based mimics effectively react with a wide range of free radicals, and their specificity for hydrogen peroxide is rather limited
It adversely affects brain homeostasis through BBB dysfunction and hyperthermia ( Various METH dosing paradigms significantly disturb endothelial TJ assembly by inducing downregulation, fragmentation, or redistribution of major TJ proteins, including claudin-5 and ZO-1, which are mediated by MMP-1 and MMP-9 peptidases
(1996) 496 (Pt 1):1039
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