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Amino acid metabolism can alter the chromatin accessibility of inflammation-related genes by influencing SAM availability and methylation potential, thereby forming a regulatory loop of metabolism-epigenetics-phenotypic stability in chronic inflammatory environments ( 2 S system related to sulfur-containing amino acids can regulate ROS buffering capacity and mitochondrial function, and may exert tissue-protective effects in some inflammatory settings while producing immunosuppressive effects under specific conditions, thereby exhibiting marked environmental dependence (133)
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Cell biology of H2O2 generation in the thyroid: investigation of the control of dual oxidases (DUOX) activity in intact ex vivo thyroid tissue and cell lines
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