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It technically adds water
This review aims to synthesise and compare the safety profiles of incretin-based therapies, including GLP-1 receptor agonists for Obesity and Type 2 Diabetes, by integrating clinical and mechanistic evidence and to identify evidence-based strategies for risk mitigation and safe clinical use
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Its too early to say which next-gen therapies will win this category, but any drug with major tolerability flags or safety overhangs even if rare will have a harder time crossing the adoption chasm
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