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In human thyroid cancer, GPx3 is frequently methylated, and the expression of GPx3 is regulated by methylation of the promoter region, and this methylation is related to tumor size and lymph node metastasis through the inhibition of Wnt/-catenin signaling [100]
SCFAs do this by activating G-protein-coupled receptors (such as GPR41 and GPR43) on L-cells, triggering intracellular signaling that increases GLP-1 release
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