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My recommended Melanotan 2 protocol is 0.25 mg injected subcutaneously, 1-2 times per week, which minimizes MC4R-driven side effects while still driving melanogenesis through MC1R
In large RCTs, patients receiving semaglutide, 2.4 mg, lost a mean of 6% of their weight by week 12 and 12% of their weight by week 28
Moura FA, Scirica BM, Ruff CT
Both have established efficacy and safety data and approved prescribing pathways, whereas Retatrutide remains investigational pending Phase 3 outcomes
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