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Journal of Hepatology 53 , 10851094, doi: 10.1016/j.jhep.2010.05.028 (2010)

doi: 10.1515/iss-2017-0010 161

nearly all efficacy evidence comes from animal or in vitro studies Fewer than 10 small human studies exist, none tracking use beyond about 12 weeks, so long-term safety (including cancer or fertility risk) is unknown Currently sits in a regulatory gray zone, complicating legitimate sourcing and quality assurance Side Effects: Most commonly reported issues are mild and short-lived: injection site soreness or reactions, occasional nausea, headache, and mild dizziness, typically resolving within hours to days

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