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For conditions where there are defective nerves, such as peripheral neuropathy, neuralgia, and Mortons neuroma or any interspace perineural neuritis, injecting a concentrated B12 dose directly around the nerve has been shown to promote nerve repair and diminish pain from nerve damage

similarly, while the niacinamide in this compounded B-Complex is in a moderate dose, caution is advised in patients with untreated peptic ulcers or significant hepatic impairment, as even moderate niacin supplementation could aggravate these conditions (e.g

Other factors contributing to neuronal death include the aggregation of proteins into Lewy bodies, the accumulation of oxidative stress, and mitochondrial dysfunction