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Mechanism of Action Semaglutide works by mimicking the action of the GLP-1 hormone
In a 2026 editorial commentary published in Cureus , citing findings from the STEP 4 and SURMOUNT 4 clinical trials, the author described how stopping GLP-1 medication may unmask counter-regulatory hunger signals including potential changes in ghrelin activity that had been suppressed while the medication was active (Quimbayo-Cifuentes, 2026)
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