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Similar to the statin lipid-lowering drugs mentioned earlier, other lipid-lowering drugs, such as probucol, also exhibit the capability to restore the inhibited GSH system and defend the myocardium from oxidative damage after exposure to pathological factors, for example, ISO and cyclophosphamide [242, 243]
PMID: 227 TurnerNCOliveiraMHowellSJDalencFCortesJGomez MorenoHLet al
Actually, I was involved with one of them, Rimonabant and did the large trial, which as you know, led to having to stop the drug, discontinue it because it was associated with suicidal ideation and actual some suicide
Consequently, the presence of a signal should be interpreted as an indication of potential risk that needs to be further evaluated in the context of robust, well-controlled clinical studies
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