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Cognitive disorders Pre-clinical and mechanistic studies Our search retrieved a high number ( N = 189) of pre-clinical or mechanistic studies assessing the possible effects of GLP-1RAs on cognitive disorders, which cannot be described in the main text of this article due to space constraints (Supplementary Section 4)
These can include nausea, vomiting of undigested food, abdominal pain, bloating, severe dehydration, a sense of fullness after only a few bites, solidification of undigested food within the stomach, acid reflux, fluctuating blood sugar readings, reduced appetite, weight loss, undernutrition, and a diminished overall quality of life
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Standard GLP-1 eligibility thresholds - based on the FDA-approved drug labeling for Wegovy and Zepbound, which guides how clinicians think about the category - generally include a BMI of 30 or higher (obese), or a BMI of 27 or higher with at least one weight-related comorbidity such as high blood pressure, high cholesterol, or type 2 diabetes
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