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The 4 mg arm landed near the territory that semaglutide occupies, the 8 mg arm matched what tirzepatide achieves at its top dose, and the 12 mg arm went somewhere no single or dual agonist had reached in a trial of that size

While empagliflozin's mechanism could theoretically offer benefits by removing excess glucose through the urine, there is a risk of diabetic ketoacidosis (DKA), especially when insulin levels are too low