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2005;82(1 Suppl):222s-s225

July 2024: Roche reported early clinical data for CT-996, its once-daily oral GLP-1 receptor agonist, showing clinically meaningful weight loss after four weeks and supporting further development in obesity and type 2 diabetes

Targeting this population would allow a more accurate assessment of whether metabolic modulation can meaningfully influence immune dysregulation at a stage when disease processes may still be reversible

SURMOUNT-2 also met all of its key secondary endpoints, with more patients in both tirzepatide groups achieving 10%, 15% and 20% body weight loss compared to patients in the placebo group, for both estimands ( Figure 9 - 19C-D )