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Post-inflammatory hyperpigmentation (PIH) is a significant concern in Indian skin populations

The current comprehensive review combines fragmented knowledge on Lentinula edodes (Berk) and presents a consolidated account that spans its cultivation, nutrition, medicinal relevance, and environmental sustainability

HFF-1 cells maintained in a T-25 cell culture flask (Corning, United States) at 37C in a 5% (v/v) CO 2 atmosphere and harvested at 90% confluence using 0.12% trypsin-EDTA

Several factors contribute to this condition, including genetics, nutritional deficiencies, chronic stress, thyroid disorders and lifestyle