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Transdermal delivery requires ingredients to cross the stratum corneum, the outermost layer of skin, which is specifically designed to keep foreign substances out
That was always a struggle for me
Science 271:813815 Eliasson L, Ma S, Renstrm E, Barg S, Berggren PO, Galvanovskis J, Gromada J, Jing X, Lundquist I, Salehi A, Sewing S, Rorsman P (2003) SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells
Uncontrolled blood sugar during pregnancy carries its own serious risks for birth defects and complications
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