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Poor responders or those with particularly stubborn chronic conditions may benefit from longer treatment phases before breaks

This could make it potentially useful in the treatment of visceral pain, anxiety conditions that might be associated with it, or chronic pain, for example [15]

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193 Furthermore, combining DDR inhibitors with ICB enhances antitumor immunity by promoting neoantigen exposure, micronuclei formation, and activation of the cGASSTING pathway