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Correspondingly, ASBEs were also modulated the expression of STAT3 and caspase 3 proteins and displayed protective role against oxidative and nitrosative stress (426)
Collectively, these analyses indicate that effective dual PDE1B/PDE10A inhibitors will require finely tuned physicochemical properties, strong metabolic stability, and minimal efflux liability to achieve sustained brain exposure with adequate selectivity
The GSH system is the central antioxidant defense system in mammalian cells, including neurons and glia
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