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As the New Year approaches, many consumers are comparing prescription-based weight management programs with lower-cost, non-prescription wellness productsespecially products marketed online as "GLP-1 patches." If you have been seeing ads for these and are unsure what is real or just marketing, you are not alone

Larger, long-term randomized controlled trials are needed to validate their efficacy, optimize dosing, and determine their role as standalone or adjunctive therapies, particularly in patients without metabolic comorbidities

Long-Term Safety Considerations As a relatively new class of medications, the long-term safety profile of GLP-1 agonists is still under evaluation

The canonical pyroptosis pathway is initiated by the activation of the NLRP3 inflammasome complex, which includes NLRP3, the adaptor protein ASC containing the CARD domain, and pro-caspase-1 [65]