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Mitochondrial dysfunction plays a central role in AD pathophysiology, but sex differences in mitochondrial function remain poorly defined
Notably, older adults with obesity and preserved baseline muscle mass represent a particularly understudied phenotype, and dedicated studies are needed to determine whether this subgroup may differentially benefit from the muscle quality improvements associated with GLP-1 RA therapy
Contrasting these positive findings, an extensive Cochrane meta-analysis of 82 studies concluded that the ability of probiotics to abbreviate the duration of acute infectious diarrhea, while detectable, is modest and remains surrounded by significant uncertainty (381)
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