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The antidepressant bupropion is also frequently linked to insomnia because of its specific effects on norepinephrine and dopamine (Schweitzer & Malhotra, 2022)

it remains investigational under Phase 3 trials, and patients should explore NICE-approved alternatives such as Wegovy or Mounjaro through their GP

In their meta-analysis combining the results of twelve randomized controlled trials, Veronese and colleagues reported a significant decrease in depression severity after acetylcarnitine supplementation as monotherapy compared with placebo intake or no intervention [143]

Some users feel disappointed if they do not experience rapid weight loss, and this can fuel skepticism