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All subjects answered a questionnaire for self-assessment

As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

This makes it a relatively uncommon but well-documented side effect

Phase 2 data demonstrated LDL cholesterol reductions of approximately 20%, a finding researchers have attributed to glucagon agonism-mediated effects on PCSK9 degradation