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When essential protein components of the transport machinery are defective or missing, such as ADP-ribosylation factor 1 (ARF1), small GTP-binding protein 1 (SAR1), the guanine-nucleotide exchange factor Golgi-Brefeldin A resistance factor (GBF1), or the coatamer proteins coat-complex I (COPI) and COPII, ATGL translocation to LD is blocked and the enzyme remains associated with the ER

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The findings related to waist circumference related to a categorical weight loss of at least 5%, 10%, or 15% by week 26 of treatment administration