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Our study indicates that upregulation of p53-pS15 and p16 maintains a persistent senescent microenvironment to promote cell cycle arrest and apoptosis resistance in keloid fibroblasts
For many patients on the weight-loss medications known as GLP-1s (glucagon-like peptide-1s), such as semaglutide, tirzepatide and liraglutide, the question of when or whether to stop is inevitable
GLP-1R was found in 83% of the activated PSCs
Future studies should focus on identifying its active constituents, elucidating detailed mechanisms of action, and validating its efficacy in well-designed clinical trials
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